Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.

doi:10.1038/s41586-020-2968-3

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Article

Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.

Nature - 1 Dec 2020

Jayavelu Ashok Kumar, Schnöder Tina M, Perner Florian, Herzog Carolin, Meiler Arno, Krishnamoorthy Gurumoorthy, Huber Nicolas, Mohr Juliane, Edelmann-Stephan Bärbel, Austin Rebecca, Brandt Sabine, Palandri Francesca, Schröder Nicolas, Isermann Berend, Edlich Frank, Sinha Amit U, Ungelenk Martin, Hübner Christian A, Zeiser Robert, Rahmig Susann, Waskow Claudia, Coldham Iain, Ernst Thomas, Hochhaus Andreas, Jilg Stefanie, Jost Philipp J, Mullally Ann, Bullinger Lars, Mertens Peter R, Lane Steven W, Mann Matthias, Heidel Florian H

Abstract excerpt

Janus kinases (JAKs) mediate responses to cytokines, hormones and growth factors in haematopoietic cells1,2. The JAK gene JAK2 is frequently mutated in the ageing haematopoietic system3,4 and in haematopoietic cancers5. JAK2 mutations constitutively activate downstream signalling and are drivers of myeloproliferative neoplasm (MPN). In clinical use, JAK inhibitors have mixed effects on the overall disease burden...

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PMID: 33239784
DOI: 10.1038/s41586-020-2968-3

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