Article

Conserved roles of RECQ-like helicases Sgs1 and BLM in preventing R-loop associated genome instability

2017-03-23

Abstract excerpt

Sgs1 is a yeast DNA helicase functioning in DNA replication and repair, and is the orthologue of the human Bloom’s syndrome helicase BLM. Here we analyze the mutation signature associated with SGS1 deletion in yeast, and find frequent copy number changes flanked by regions of repetitive sequence and high R-loop forming potential. We show that loss of SGS1 increases R-loop accumulation and sensitizes cells to rep...

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Literature Corpus work: 87b9eba6-4dbf-5e89-b319-f2c526cfc567
DOI: 10.1101/119677

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