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Article

Bloom's syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Nov 1999

Heo S J, Tatebayashi K, Ohsugi I, Shimamoto A, Furuichi Y, Ikeda H

Abstract excerpt

BACKGROUND: Bloom's syndrome (BS) is an autosomal recessive disorder causing short stature, immunodeficiency, and an increased risk of cancer. Increased rates of sister chromatid exchange and chromosomal aberration have been observed in cells having defects in the BLM gene. Among five kinds of human RecQ helicases cloned, the mutations in WRN and RecQL4 have been known as the causes of premature ageing. Little...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10620009
DOI: 10.1046/j.1365-2443.1999.00288.x

Genes

BLM
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bloom's syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast.PMID 10620009Read ↗

Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases.Semantic proximity Read ↗

SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae.Semantic proximity Read ↗

Maintenance of Yeast Genome Integrity by RecQ Family DNA Helicases.Semantic proximity Read ↗

Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases.Semantic proximity Read ↗

RECQ-like helicases Sgs1 and BLM regulate R-loop–associated genome instabilitySemantic proximity Read ↗

Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system.Semantic proximity Read ↗

Conserved roles of RECQ-like helicases Sgs1 and BLM in preventing R-loop associated genome instabilitySemantic proximity Read ↗

SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination.Semantic proximity Read ↗

Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases.Semantic proximity Read ↗

An essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs.Semantic proximity Read ↗

Vertebrate WRNIP1 and BLM are required for efficient maintenance of genome stability.Semantic proximity Read ↗

Evidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence.Semantic proximity Read ↗

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