Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs.

The EMBO journal - 19 May 2010

Chen Chi-Fu, Brill Steven J

Abstract excerpt

The gene mutated in Bloom's syndrome, BLM, encodes a member of the RecQ family of DNA helicases that is needed to suppress genome instability and cancer predisposition. BLM is highly conserved and all BLM orthologs, including budding yeast Sgs1, have a large N-terminus that binds Top3-Rmi1 but has no known catalytic activity. In this study, we describe a sub-domain of the Sgs1 N-terminus that shows in vitro...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bloom Syndrome
Share to Conserved Sequence
Share to DNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Single-Stranded

Share to Drosophila melanogaster

Share to Kinetics

Share to RecQ Helicases

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 20389284
DOI: 10.1038/emboj.2010.61
PMCID: PMC2876966

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs.PMID 20389284Read ↗

RECQ-like helicases Sgs1 and BLM regulate R-loop–associated genome instabilitySemantic proximity Read ↗

Conserved roles of RECQ-like helicases Sgs1 and BLM in preventing R-loop associated genome instabilitySemantic proximity Read ↗

DNA helicases Sgs1 and BLM promote DNA double-strand break resection.Semantic proximity Read ↗

Bipartite structure of the SGS1 DNA helicase in Saccharomyces cerevisiae.Semantic proximity Read ↗

Sgs1 regulates gene conversion tract lengths and crossovers independently of its helicase activity.Semantic proximity Read ↗

Maintenance of Yeast Genome Integrity by RecQ Family DNA Helicases.Semantic proximity Read ↗

Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair.Semantic proximity Read ↗

SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination.Semantic proximity Read ↗

Genetic analysis of the Saccharomyces cerevisiae Sgs1 helicase defines an essential function for the Sgs1-Top3 complex in the absence of SRS2 or TOP1.Semantic proximity Read ↗

Vertebrate WRNIP1 and BLM are required for efficient maintenance of genome stability.Semantic proximity Read ↗

Sgs1 Binding to Rad51 Stimulates Homology-Directed DNA Repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

Functions of the Bloom Syndrome Helicase N-terminal Intrinsically Disordered RegionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.