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Article

Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair.

The EMBO journal - 8 Apr 2009

Bernstein Kara A, Shor Erika, Sunjevaric Ivana, Fumasoni Marco, Burgess Rebecca C, Foiani Marco, Branzei Dana, Rothstein Rodney

Abstract excerpt

Mutations in human homologues of the bacterial RecQ helicase cause diseases leading to cancer predisposition and/or shortened lifespan (Werner, Bloom, and Rothmund-Thomson syndromes). The budding yeast Saccharomyces cerevisiae has one RecQ helicase, Sgs1, which functions with Top3 and Rmi1 in DNA repair. Here, we report separation-of-function alleles of SGS1 that suppress the slow growth of top3Delta and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Microscopy, Fluorescence

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Source

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Identifiers

PMID: 19214189
DOI: 10.1038/emboj.2009.28
PMCID: PMC2670856

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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