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Sgs1 regulates gene conversion tract lengths and crossovers independently of its helicase activity.

Molecular and cellular biology - 1 Jun 2006

Lo Yi-Chen, Paffett Kimberly S, Amit Or, Clikeman Jennifer A, Sterk Rosa, Brenneman Mark A, Nickoloff Jac A

Abstract excerpt

RecQ helicases maintain genome stability and suppress tumors in higher eukaryotes through roles in replication and DNA repair. The yeast RecQ homolog Sgs1 interacts with Top3 topoisomerase and Rmi1. In vitro, Sgs1 binds to and branch migrates Holliday junctions (HJs) and the human RecQ homolog BLM, with Top3alpha, resolves synthetic double HJs in a noncrossover sense. Sgs1 suppresses crossovers during the...

Topics

Chromosome Segregation
Chromosomes, Fungal
Crossing Over, Genetic
DNA Damage
DNA Helicases
Gene Conversion
Gene Expression Regulation, Fungal
Methyl Methanesulfonate
Mutation
RecQ Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 16705162
DOI: 10.1128/MCB.00136-06
PMCID: PMC1489077

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Sgs1 regulates gene conversion tract lengths and crossovers independently of its helicase activity.PMID 16705162Read ↗

Sgs1 Binding to Rad51 Stimulates Homology-Directed DNA Repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination.Semantic proximity Read ↗

An essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs.Semantic proximity Read ↗

Sgs1's roles in DNA end resection, HJ dissolution, and crossover suppression require a two-step SUMO regulation dependent on Smc5/6.Semantic proximity Read ↗

Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair.Semantic proximity Read ↗

Genetic analysis of the Saccharomyces cerevisiae Sgs1 helicase defines an essential function for the Sgs1-Top3 complex in the absence of SRS2 or TOP1.Semantic proximity Read ↗

DNA helicases Sgs1 and BLM promote DNA double-strand break resection.Semantic proximity Read ↗

Control of translocations between highly diverged genes by Sgs1, the Saccharomyces cerevisiae homolog of the Bloom's syndrome protein.Semantic proximity Read ↗

Maintenance of Yeast Genome Integrity by RecQ Family DNA Helicases.Semantic proximity Read ↗

The genetic consequences of ablating helicase activity and the Top3 interaction domain of Sgs1.Semantic proximity Read ↗

Conserved roles of RECQ-like helicases Sgs1 and BLM in preventing R-loop associated genome instabilitySemantic proximity Read ↗

RECQ-like helicases Sgs1 and BLM regulate R-loop–associated genome instabilitySemantic proximity Read ↗

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