Article
Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 1998
Yamagata K, Kato J, Shimamoto A, Goto M, Furuichi Y, Ikeda H
Abstract excerpt
Bloom's syndrome (BS) and Werner's syndrome (WS) are genetic disorders in which an increased rate of chromosomal aberration is detected. The genes responsible for these diseases, BLM and WRN, have been found to be homologs of Escherichia coli recQ and Saccharomyces cerevisiae SGS1 genes. Here we...
Topics
- Base Sequence
- Bloom Syndrome
- DNA
- DNA Helicases
- Humans
- Hydroxyurea
- Mutation
- RecQ Helicases
- Recombination, Genetic
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Sequence Homology, Nucleic Acid
- Werner Syndrome