Article

MeDEStrand: an improved method to infer genome-wide absolute methylation level from DNA enrichment experiment

2017-09-27

Abstract excerpt

<h4>Background</h4> DNA methylation of dinucleotide CpG is an essential epigenetic modification that plays a key role in transcription. Bisulfite conversion method is a “gold standard” for DNA methylation profiling that provides single nucleotide resolution. However, whole-genome bisulfite conversion is very expensive. Alternatively, DNA enrichment-based methods offer high coverage of methylated CpG dinucleotides...

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Literature Corpus work: 87abd833-468c-5c37-b077-621676cf34f4
DOI: 10.1101/194431

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