Article
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications.
Nature biotechnology - 1 Oct 2010
Harris R Alan, Wang Ting, Coarfa Cristian, Nagarajan Raman P, Hong Chibo, Downey Sara L, Johnson Brett E, Fouse Shaun D, Delaney Allen, Zhao Yongjun, Olshen Adam, Ballinger Tracy, Zhou Xin, Forsberg Kevin J, Gu Junchen, Echipare Lorigail, O'Geen Henriette, Lister Ryan, Pelizzola Mattia, Xi Yuanxin, Epstein Charles B, Bernstein Bradley E, Hawkins R David, Ren Bing, Chung Wen-Yu, Gu Hongcang, Bock Christoph, Gnirke Andreas, Zhang Michael Q, Haussler David, Ecker Joseph R, Li Wei, Farnham Peggy J, Waterland Robert A, Meissner Alexander, Marra Marco A, Hirst Martin, Milosavljevic Aleksandar, Costello Joseph F
Abstract excerpt
Analysis of DNA methylation patterns relies increasingly on sequencing-based profiling methods. The four most frequently used sequencing-based technologies are the bisulfite-based methods MethylC-seq and reduced representation bisulfite sequencing (RRBS), and the enrichment-based techniques methylated DNA immunoprecipitation sequencing (MeDIP-seq) and methylated DNA binding domain sequencing (MBD-seq). We applied...
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