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An optimized algorithm for detecting and annotating regional differential methylation

1 Apr 2013

Abstract excerpt

BACKGROUND: DNA methylation profiling reveals important differentially methylated regions (DMRs) of the genome that are altered during development or that are perturbed by disease. To date, few programs exist for regional analysis of enriched or whole-genome bisulfate conversion sequencing data, even though such data are increasingly common. Here, we describe an open-source, optimized method for determining...

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PMID: 23735126
DOI: 10.1186/1471-2105-14-s5-s10

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