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Reconstructing complex cancer evolutionary histories from multiple bulk DNA samples using Pairtree

2020-11-08

Abstract excerpt

Cancers are composed of genetically distinct subpopulations of malignant cells. By sequencing DNA from cancer tissue samples, we can characterize the somatic mutations specific to each population and build clone trees describing the evolutionary ancestry of populations relative to one another. These trees reveal critical points in disease development and inform treatment. Pairtree constructs clone trees using DNA...

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Identifiers and source

Literature Corpus work
87a54227-7970-543c-8dda-ce6271e16df7
DOI
10.1101/2020.11.06.372219
Open publication

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Reconstructing complex cancer evolutionary histories from multiple bulk DNA samples using PairtreeDOI 10.1101/2020.11.06.372219
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