Article

Both cell autonomous and non-autonomous processes modulate the association between replication timing and mutation rate

2022-10-07

Abstract excerpt

Cancer somatic mutations are the product of multiple mutational and repair processes, both of which are tightly associated with DNA replication. Mutation rates (MR) are known to be higher in late replication timing (RT) regions, but different processes can affect this association. Systematic analysis of the mutational landscape of 2,787 tumors from 32 tumor types revealed that the tumors can be divided into two gr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 74d703b0-8169-5196-862e-7d3981be8c66
DOI: 10.1101/2022.10.03.510640

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Both cell autonomous and non-autonomous processes modulate the association between replication timing and mutation rateDOI 10.1101/2022.10.03.510640Read

Both cell autonomous and non-autonomous processes modulate the association between replication timing and mutation rateSemantic proximity Read

Both cell autonomous and non-autonomous processes modulate the association between replication timing and mutation rate.Semantic proximity Read

Complex correlations: replication timing and mutational landscapes during cancer and genome evolution.Semantic proximity Read

Mutational signatures association with replication timing in normal cells reveals similarities and differences with matched cancer tissues.Semantic proximity Read

Multifactorial heterogeneity of the human mutation landscape related to DNA replication dynamicsSemantic proximity Read

Cancer Mutational Processes Vary in Their Association with Replication Timing and Chromatin Accessibility.Semantic proximity Read

Unveiling Replication Timing-Dependent Mutational Biases: Mechanistic Insights from Gene Knockouts and Genotoxins Exposures.Semantic proximity Read

Cancer mutational processes vary in their association with replication timing and chromatin accessibilitySemantic proximity Read

Replication timing alterations are associated with mutation acquisition during breast and lung cancer evolution.Semantic proximity Read

Widespread impact of DNA replication on mutational mechanisms in cancerSemantic proximity Read

Human mutation rate associated with DNA replication timing.Semantic proximity Read

The role of somatic mutations and cell replication kinetics in quantitative cancer risk assessment.Semantic proximity Read