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Article

Cancer Mutational Processes Vary in Their Association with Replication Timing and Chromatin Accessibility.

Cancer research - 15 Dec 2021

Yaacov Adar, Vardi Oriya, Blumenfeld Britny, Greenberg Avraham, Massey Dashiell J, Koren Amnon, Adar Sheera, Simon Itamar, Rosenberg Shai

Abstract excerpt

Cancer somatic mutations are the product of multiple mutational and repair processes, both of which are tightly associated with DNA replication. Distinctive patterns of somatic mutation accumulation, termed mutational signatures, are indicative of processes sustained within tumors. However, the association of various mutational processes with replication timing (RT) remains an open question. In this study, we...

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Identifiers

PMID: 34702725
DOI: 10.1158/0008-5472.CAN-21-2039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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