Article

Palette polygenic risk score framework improves risk prediction by capturing clinical heterogeneity of type 2 diabetes

2026-01-13

Abstract excerpt

Polygenic risk scores (PRSs) are typically constructed under the assumption of a single, homogeneous disease phenotype. However, many common diseases exhibit considerable clinical heterogeneity and encompass multiple subtypes with distinct etiologies and clinical characteristics. As a result, conventional PRSs often overlook differences in underlying biological pathways among disease subtypes, consequently limitin...

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Literature Corpus work: 876a7fb9-a794-5dd0-ad6c-6672eae69e6b
DOI: 10.64898/2026.01.12.25342123

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