Article

Baicalin restores metformin responsiveness by inhibiting ceramide biosynthesis via SPT and pPP2A/pAMPK axis

2026-03-06

Abstract excerpt

<h4>Background: </h4> and Purpose: The rising prevalence of metformin non-response in type 2 diabetes mellitus (T2DM) presents a major therapeutic hurdle. While baicalin combined with metformin exerts a synergistic hypoglycemic effect, the underlying mechanism of this combination therapy remains unclear. We identified the key regulatory metabolite of the baicalin-metformin combination via metabolomics, and clarifi...

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Literature Corpus work: 87595ee0-8ba5-5a38-a458-0ee4dc5868a5
DOI: 10.22541/au.177279692.29177541/v1

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