Article

Lac-Phe mediates the anti-obesity effect of metformin

2023-11-04

Abstract excerpt

Metformin is a widely prescribed anti-diabetic medicine that also reduces body weight. The mechanisms that mediate metformin’s effects on energy balance remain incompletely defined. Here we show that metformin is a powerful pharmacological inducer of the anorexigenic metabolite Lac-Phe in mice as well as in two independent human cohorts. In cell culture, metformin drives Lac-Phe biosynthesis via inhibition of comp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 94762ee2-50a8-5314-8cd1-0ce2bb0155b2
DOI: 10.1101/2023.11.02.565321

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lac-Phe mediates the anti-obesity effect of metforminDOI 10.1101/2023.11.02.565321Read

Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycemic controlSemantic proximity Read

Metformin pathwaysSemantic proximity Read

Metformin: an old drug with potential therapeutic function in antitumorSemantic proximity Read

Function and therapeutic potential of metformin in multiple diseasesSemantic proximity Read

Cellular and Molecular Mechanisms of Metformin ActionSemantic proximity Read

Anti-tumor activity of metformin: from metabolic and epigenetic perspectivesSemantic proximity Read

Molecular mechanism of action of metformin: old or new insights?Semantic proximity Read

Metabolic defects cause hyperactive mitochondria and Parkinson’s disease-like traitsSemantic proximity Read

Targeting Myotonic Dystrophy Type 1 with Metformin.Semantic proximity Read

Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis.Semantic proximity Read

Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose MetabolismSemantic proximity Read

Is Metformin a Perfect Drug? Updates in Pharmacokinetics and Pharmacodynamics.Semantic proximity Read