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Phenotypic screening in zebrafish larvae identifies promising cyanobacterial strains and pheophorbide a as insulin mimetics.

Scientific reports - 30 Dec 2024

Ribeiro Tiago, Reis Mariana, Vasconcelos Vitor, Urbatzka Ralph

Abstract excerpt

Diabetes is a pandemic disease that causes the loss of control of glucose regulation in the organism, in consequence of dysfunction of insulin production or functionality. In this work, the antidiabetic bioactivity of 182 fractions from 19 cyanobacteria strains derived from the LEGE Culture Collection were analysed using the 2-NBDG assay in zebrafish larvae. From this initial screening, two fractions (57...

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Identifiers

PMID: 39739113
DOI: 10.1038/s41598-024-83986-0
PMCID: PMC11685485

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