Article

Ceramide Synthases Regulate Myristate-Induced Intestinal IRE1α Activation

2026-05-31

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background & Aims</h4> High-fat diets (HFDs) are a major modifiable risk factor for intestinal health. Current research focuses primarily on palmitate (C16:0); however, myristate (C14:0, rich in dairy products) has been minimally investigated. HFDs increase ceramide generation which drives endoplasmic reticulum (ER) stress; with both sphingolipids and ER stress being key contributors to int...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cadf3823-c644-57ea-9598-6be54dc0a7d6
DOI: 10.64898/2026.05.28.728542

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ceramide Synthases Regulate Myristate-Induced Intestinal IRE1α ActivationDOI 10.64898/2026.05.28.728542Read

IL-10 constrains sphingolipid metabolism via fatty acid desaturation to limit inflammationSemantic proximity Read

Lipid perturbation-activated IRE-1 modulates autophagy and lipolysis during endoplasmic reticulum stressSemantic proximity Read

Interplay between ceramides and phytonutrients: New insights in metabolic syndromeSemantic proximity Read

<i>Salmonella</i> lipopolysaccharide stimulates uptake of long-chain fatty acids in the small intestineSemantic proximity Read

Conjugated Linoleic Acid Ameliorates High Fat-Induced Insulin Resistance via Regulating Gut Microbiota–Host Metabolic and Immunomodulatory InteractionsSemantic proximity Read

Sphingolipid production by gut Bacteroidetes regulates glucose homeostasisSemantic proximity Read

The dietary emulsifier polysorbate-80 induces lipid accumulation and cell death in intestinal epithelial cells via ferroptosisSemantic proximity Read

Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels.Semantic proximity Read

Dietary fat enhanced chylomicron-mediated LPS translocation in a Caco-2 transwell modelSemantic proximity Read

Dysregulated phosphatidylinositol signaling promotes endoplasmic-reticulum-stress-mediated intestinal mucosal injury and inflammation in zebrafish.Semantic proximity Read

Impaired Chylomicron Secretion Results in Reduced Body Fat and Increased Intestinal Fatty Acid Oxidation by Activation of AutophagySemantic proximity Read

Dietary bacteria control <i>C. elegans</i> fat content through pathways converging at phosphatidylcholineSemantic proximity Read