Article
Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels.
Nature communications - 18 May 2020
Johnson Elizabeth L, Heaver Stacey L, Waters Jillian L, Kim Benjamin I, Bretin Alexis, Goodman Andrew L, Gewirtz Andrew T, Worgall Tilla S, Ley Ruth E
Abstract excerpt
Gut microbes are linked to host metabolism, but specific mechanisms remain to be uncovered. Ceramides, a type of sphingolipid (SL), have been implicated in the development of a range of metabolic disorders from insulin resistance (IR) to hepatic steatosis. SLs are obtained from the diet and generated by de novo synthesis in mammalian tissues. Another potential, but unexplored, source of mammalian SLs is...
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