Article
Metformin impairs systemic bile acid homeostasis through regulating SIRT1 protein levels.
Biochimica et biophysica acta. Molecular cell research - 1 Jan 2017
Chen Qi, Yang Xiaoying, Zhang Huabing, Kong Xingxing, Yao Lu, Cui Xiaona, Zou Yongkang, Fang Fude, Yang Jichun, Chang Yongsheng
Abstract excerpt
Metformin is widely used to treat hyperglycemia. However, metformin treatment may induce intrahepatic cholestasis and liver injury in a few patients with type II diabetes through an unknown mechanism. Here we show that metformin decreases SIRT1 protein levels in primary hepatocytes and liver. Both metformin-treated wild-type C57 mice and hepatic SIRT1-mutant mice had increased hepatic and serum bile acid levels....
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