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Mutations in the gdpP gene are a clinically relevant mechanism for β-lactam resistance in meticillin-resistant Staphylococcus aureus lacking mec determinants.

Microbial genomics - 1 Sept 2021

Sommer Anna, Fuchs Stephan, Layer Franziska, Schaudinn Christoph, Weber Robert E, Richard Hugues, Erdmann Mareike B, Laue Michael, Schuster Christopher F, Werner Guido, Strommenger Birgit

Abstract excerpt

In Staphylococcus aureus, resistance to β-lactamase stable β-lactam antibiotics is mediated by the penicillinbinding protein 2a, encoded by mecA or by its homologues mecB or mecC. However, a substantial number of meticillin-resistant isolates lack known mec genes and, thus, are called meticillin resistant lacking mec (MRLM). This study aims to identify the genetic mechanisms underlying the MRLM phenotype. A total...

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Identifiers

PMID: 34486969
DOI: 10.1099/mgen.0.000623
PMCID: PMC8715439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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