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Article

Altered PBP4 and GdpP functions synergistically mediate MRSA-like high-level, broad-spectrum β-lactam resistance in Staphylococcus aureus.

mBio - 8 May 2024

Lai Li-Yin, Satishkumar Nidhi, Cardozo Sasha, Hemmadi Vijay, Marques Leonor B, Huang Liusheng, Filipe Sergio R, Pinho Mariana G, Chambers Henry F, Chatterjee Som S

Abstract excerpt

Infections caused by Staphylococcus aureus are a leading cause of mortality worldwide. S. aureus infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are particularly difficult to treat due to their resistance to next-generation β-lactams (NGBs) such as methicillin, nafcillin, and oxacillin. Resistance to NGBs, which is alternatively known as broad-spectrum β-lactam resistance, is classically...

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Identifiers

PMID: 38530033
DOI: 10.1128/mbio.02889-23
PMCID: PMC11077961

Genes

NGB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Altered PBP4 and GdpP functions synergistically mediate MRSA-like high-level, broad-spectrum β-lactam resistance in Staphylococcus aureus.PMID 38530033Read ↗

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