Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Truncation of GdpP mediates β-lactam resistance in clinical isolates of Staphylococcus aureus

8 Feb 2019

Abstract excerpt

OBJECTIVES: High-level β-lactam resistance in MRSA is mediated in the majority of strains by a mecA or mecC gene. In this study, we identified 10 mec gene-negative MRSA human isolates from Austria and 11 bovine isolates from the UK showing high levels of β-lactam resistance and sought to understand the molecular basis of the resistance observed. METHODS: Different antimicrobial resistance testing methods (disc...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotic Resistance in Bacteria
Share to Antimicrobial Resistance in Staphylococcus
Share to Clostridium difficile and Clostridium perfringens research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30759229
DOI: 10.1093/jac/dkz013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Truncation of GdpP mediates β-lactam resistance in clinical isolates of Staphylococcus aureusPMID 30759229Read ↗

Mutations in the gdpP gene are a clinically relevant mechanism for β-lactam resistance in meticillin-resistant Staphylococcus aureus lacking mec determinants.Semantic proximity Read ↗

Altered PBP4 and GdpP functions synergistically mediate MRSA-like high-level, broad-spectrum β-lactam resistance in Staphylococcus aureus.Semantic proximity Read ↗

Loss of GdpP function in <i>Staphylococcus aureus</i> leads to β-lactam tolerance and enhanced evolution of β-lactam resistanceSemantic proximity Read ↗

An Update on the Role of Penicillin Binding Protein-4 (PBP4) in β-Lactam Resistance of <em>Staphylococcus aureus</em>Semantic proximity Read ↗

Loss of GdpP function in <i>Staphylococcus aureus</i> confers β-lactam-specific antibiotic tolerance and promotes invasive infectionSemantic proximity Read ↗

Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.Semantic proximity Read ↗

Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec geneSemantic proximity Read ↗

Modified methicillin-resistant Staphylococcus aureus detected in neonatal intensive care patientsSemantic proximity Read ↗

A MRSA mystery: how PBP4 and cyclic-di-AMP join forces against β-lactam antibiotics.Semantic proximity Read ↗

Comprehensive Genomic Investigation of Adaptive Mutations Driving the Low-Level Oxacillin Resistance Phenotype in Staphylococcus aureus.Semantic proximity Read ↗

Methicillin Resistance Alters the Biofilm Phenotype and Attenuates Virulence in Staphylococcus aureus Device-Associated InfectionsSemantic proximity Read ↗

Evidence for the evolutionary steps leading to mecA-mediated β-lactam resistance in staphylococci.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.