Mislocalization of PBPs in Staphylococcus aureus gdpP mutant contributes to β-lactam resistance and surface protein cross-wall trafficking.

doi:10.1128/spectrum.01430-26

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Article

Mislocalization of PBPs in Staphylococcus aureus gdpP mutant contributes to β-lactam resistance and surface protein cross-wall trafficking.

Microbiology spectrum - 1 Sept 2026

Jia Yaosheng, Zhang Ran, Scaffidi Salvatore J, Yu Wenqi

Abstract excerpt

GdpP is a phosphodiesterase that degrades the second messenger c-di-AMP, which plays a key role in osmoregulation and antibiotic resistance in many gram-positive bacteria. Mutations in gdpP are frequently associated with mecA-independent β-lactam resistance in Staphylococcus aureus, but the mechanisms remain unknown. Here, we show that deletion of gdpP diminished cross-wall deposition of YSIRK+ surface protein A...

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Topics

Staphylococcus aureus
beta-Lactam Resistance
Bacterial Proteins
Cell Wall
Penicillin-Binding Proteins
Anti-Bacterial Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Protein Transport

Phosphoric Diester Hydrolases

Mutation

Membrane Proteins

beta Lactam Antibiotics

beta-Lactams

Staphylococcal Infections

Source

Open in PubMed Open full text

Identifiers

PMID: 42584155
DOI: 10.1128/spectrum.01430-26
PMCID: PMC13532199

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