Article
Ageing and mammalian mitochondrial genetics.
Trends in genetics : TIG - 1 Dec 1998
Nagley P, Wei Y H
Abstract excerpt
Mitochondrial DNA (mtDNA) is essential for the ability of mammalian cells to generate a functional oxidative phosphorylation system. Mutations in mtDNA occur in human disease and also during ageing. Here, we address three questions concerning the occurrence and accumulation of mtDNA mutations during the lifespan of the mammalian cell. What sort of mutations accumulate with age in humans and other mammals? How is...
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