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Article

cfNOMe - A single assay for comprehensive epigenetic analyses of cell-free DNA.

Genome medicine - 24 Jun 2020

Erger Florian, Nörling Deborah, Borchert Domenica, Leenen Esther, Habbig Sandra, Wiesener Michael S, Bartram Malte P, Wenzel Andrea, Becker Christian, Toliat Mohammad R, Nürnberg Peter, Beck Bodo B, Altmüller Janine

Abstract excerpt

Cell-free DNA (cfDNA) analysis has become essential in cancer diagnostics and prenatal testing. We present cfNOMe, a two-in-one method of measuring cfDNA cytosine methylation and nucleosome occupancy in a single assay using non-disruptive enzymatic cytosine conversion and a custom bioinformatic pipeline. We show that enzymatic cytosine conversion better preserves cfDNA fragmentation information than does...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 32580754
DOI: 10.1186/s13073-020-00750-5
PMCID: PMC7315486

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