Article

Vinculin organises apical Transcellular Actin Fibres to coordinate collective migration

2026-06-01

Abstract excerpt

Collective cell migration is coordinated by adherens junctions (AJs) which serve both as structural links between the actin cytoskeleton of adjacent cells, as well as mechano-transductory structures allowing cells to transmit mechanical signals. Vinculin contributes to AJ maturation in multiple ways, binding to actin and the cadherin-catenin complex, bundling actin filaments, antagonising branched actin polymerisa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 86c5b124-81cf-55bc-b9fa-50c8f5d18973
DOI: 10.64898/2026.05.29.728702

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Vinculin organises apical Transcellular Actin Fibres to coordinate collective migrationDOI 10.64898/2026.05.29.728702Read

Anillin regulates epithelial cell mechanics by structuring the medial-apical actomyosin networkSemantic proximity Read

Contractile forces at tricellular contacts modulate epithelial organization and monolayer integritySemantic proximity Read

Vinculin regulates the recruitment and release of core focal adhesion proteins in a force-dependent manner.Semantic proximity Read

Mechanical heterogeneity along single cell-cell junctions is driven by lateral clustering of cadherins during vertebrate axis elongationSemantic proximity Read

α-Catenin Controls the Anisotropy of Force Distribution at Cell-Cell Junctions during Collective Cell Migration.Semantic proximity Read

Defining functional interactions during biogenesis of epithelial junctions.Semantic proximity Read

Force-dependent vinculin binding of α-catenin accelerates adherens junction formation.Semantic proximity Read

Adhesion tunes speed and persistence by coordinating protrusions and extracellular matrix remodelingSemantic proximity Read

DOCK8 regulates a mechanosensitive actin redistribution that maintains immune cell cohesion and protects the nucleus during migrationSemantic proximity Read

Convergent extension requires adhesion-dependent biomechanical integration of cell crawling and junction contractionSemantic proximity Read

Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions.Semantic proximity Read

Vinculins interaction with talin is essential for mammary epithelial differentiation.Semantic proximity Read