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Article

Anillin regulates epithelial cell mechanics by structuring the medial-apical actomyosin network

31 Jan 2019

Abstract excerpt

Cellular forces sculpt organisms during development, while misregulation of cellular mechanics can promote disease. Here, we investigate how the actomyosin scaffold protein anillin contributes to epithelial mechanics in Xenopus laevis embryos. Increased mechanosensitive recruitment of vinculin to cell–cell junctions when anillin is overexpressed suggested that anillin promotes junctional tension. However,...

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PMID: 30702429
DOI: 10.7554/elife.39065

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