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Article

Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity

13 Jan 2017

Abstract excerpt

Monolayered epithelia are composed of tight cell assemblies that ensure polarized exchanges. EpCAM, an unconventional epithelial-specific cell adhesion molecule, is assumed to modulate epithelial morphogenesis in animal models, but little is known regarding its cellular functions. Inspired by the characterization of cellular defects in a rare EpCAM-related human intestinal disease, we find that the absence of...

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PMID: 28084299
DOI: 10.1038/ncomms13998

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