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Article

α-Catenin Controls the Anisotropy of Force Distribution at Cell-Cell Junctions during Collective Cell Migration.

Cell reports - 19 Jun 2018

Matsuzawa Kenji, Himoto Takuya, Mochizuki Yuki, Ikenouchi Junichi

Abstract excerpt

Adherens junctions (AJs) control epithelial cell behavior, such as collective movement and morphological changes, during development and in disease. However, the molecular mechanism of AJ remodeling remains incompletely understood. Here, we report that the conformational activation of α-catenin is the key event in the dynamic regulation of AJ remodeling. α-catenin activates RhoA to increase actomyosin...

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PMID: 29924989
DOI: 10.1016/j.celrep.2018.05.070

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