Deciphering the role of BRCA2 at the damage-induced G2 checkpoint

Abstract excerpt

Loss of DNA damage-induced G2 checkpoint control is associated with genome instability, tumour formation and the therapeutic response of tumours to genotoxic agents. The large 3418 residue protein encoded by BRCA2 – heterozygous germline mutations in which predispose to cancer - has recently been implicated in G2 checkpoint maintenance. However, the mechanistic basis of BRCA2’s role in the G2 checkpoint remains un...

Topics

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• Cell Cycle
• DNA Damage
• DNA Repair
• DNA Repair Mechanisms
• G2 Phase
• Mutation
• Neoplasms
• PARP inhibition in cancer therapy

Identifiers and source

Literature Corpus work

86a3b46b-f4f7-5620-bc5b-e71fa77965ea

DOI

10.17863/cam.25340