Article

Mechanisms underlying genome maintenance and tumour suppression by BRCA2

2018-01-01

Abstract excerpt

Inheritance of germline pathogenic mutations in a single BRCA2 allele predisposes carriers to cancers of the breast, ovaries, pancreas, prostate and other tissues. BRCA2 encodes a complex protein of 3418 residues, with multiple distinct regions implicated in different cellular processes including homologous recombination, replication stress tolerance, maintenance of the G2 and spindle assembly checkpoints, and in...

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Literature Corpus work: cce8ff0e-0235-50ff-bc11-3fce2ff9efa2
DOI: 10.17863/cam.25562

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