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Cell-type-specific role of CHK2 in mediating DNA damage-induced G2 cell cycle arrest

13 Mar 2020

Abstract excerpt

Cancer is a life-threatening disease that affects one in three people. Although most cases are sporadic, cancer risk can be increased by genetic factors. It remains unknown why certain genes predispose for specific forms of cancer only, such as checkpoint protein 2 (CHK2), in which gene mutations convey up to twofold higher risk for breast cancer but do not increase lung cancer risk. We have investigated the role...

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PMID: 32170104
DOI: 10.1038/s41389-020-0219-y

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