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Article

G2 damage checkpoints: what is the turn-on?

22 Dec 2004

Abstract excerpt

Cells mount a coordinated response to DNA damage, activating DNA repair pathways and cell-cycle checkpoint pathways to allow time for DNA repair to occur. In human cells, checkpoint responses can be divided into p53-dependent and p53-independent pathways, the latter being predominant in G2 phase of the cell cycle. The p53-independent pathway involves a phosphorylation cascade that activates the Chk1 effector...

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PMID: 15615778
DOI: 10.1242/jcs.01626

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