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Article

Tumour suppressor mechanisms in the control of chromosome stability: insights from BRCA2.

Molecules and cells - 1 Feb 2014

Venkitaraman Ashok R

Abstract excerpt

Cancer is unique amongst human diseases in that its cellular manifestations arise and evolve through the acquisition of somatic alterations in the genome. In particular, instability in the number and structure of chromosomes is a near-universal feature of the genomic alterations associated with epithelial cancers, and is triggered by the inactivation of tumour suppressor mechanisms that preserve chromosome...

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Source

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Identifiers

PMID: 24598993
DOI: 10.14348/molcells.2014.2346
PMCID: PMC3935635

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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