Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA damage checkpoint kinases in cancer

1 Jan 2020

Abstract excerpt

DNA damage response (DDR) pathway prevents high level endogenous and environmental DNA damage being replicated and passed on to the next generation of cells via an orchestrated and integrated network of cell cycle checkpoint signalling and DNA repair pathways. Depending on the type of damage, and where in the cell cycle it occurs different pathways are involved, with the ATM-CHK2-p53 pathway controlling the G1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cancer Research and Treatments
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32508294
DOI: 10.1017/erm.2020.3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA damage checkpoint kinases in cancerPMID 32508294Read ↗

Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA DamageSemantic proximity Read ↗

Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA DamageSemantic proximity Read ↗

Predictive and Prognostic Value of DNA Damage Response Associated Kinases in Solid TumorsSemantic proximity Read ↗

Targeting DNA repair pathway in cancer: Mechanisms and clinical applicationSemantic proximity Read ↗

DNA Damage Response Pathways in Tumor Suppression and Cancer TreatmentSemantic proximity Read ↗

Novel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti‐cancer therapy?Semantic proximity Read ↗

G2 damage checkpoints: what is the turn-on?Semantic proximity Read ↗

ATM and ATR as therapeutic targets in cancerSemantic proximity Read ↗

Activation of DNA damage response signaling in mammalian cells by ionizing radiationSemantic proximity Read ↗

Cell cycle checkpoints and their inactivation in human cancerSemantic proximity Read ↗

ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responsesSemantic proximity Read ↗

Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.