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Cell cycle checkpoints and their inactivation in human cancer

1 Oct 2000

Abstract excerpt

Checkpoints are mechanisms that regulate progression through the cell cycle insuring that each step takes place only once and in the right sequence. Mutations of checkpoint proteins are frequent in all types of cancer as defects in cell cycle control can lead to genetic instability. This review will focus on three major areas of cell cycle transition control, with particular attention to the alterations found in...

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PMID: 11063129
DOI: 10.1046/j.1365-2184.2000.00191.x

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