Article

FOXO Transcription Factors Activate Alternative Major Immediate Early Promoters to Induce Human Cytomegalovirus Reactivation

2020-02-11

Abstract excerpt

A key step during viral reactivation from latency is the re-expression of viral genes. Hematopoietic progenitor cells (HPCs) support human cytomegalovirus (HCMV) latency, and their differentiation triggers cellular cues that drive reactivation. A key step during HCMV reactivation in latently infected HPCs is re-expression of viral genes. We recently determined that the major immediate early promoter (MIEP), which...

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Literature Corpus work: 869b9f14-d0b9-5fed-b61f-b8a6d98a59d5
DOI: 10.1101/2020.02.10.942433

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