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Regulation of the MIE Locus During HCMV Latency and Reactivation

23 Oct 2020

Abstract excerpt

Human cytomegalovirus (HCMV) is a ubiquitous herpesviral pathogen that results in life-long infection. HCMV maintains a latent or quiescent infection in hematopoietic cells, which is broadly defined by transcriptional silencing and the absence of de novo virion production. However, upon cell differentiation coupled with immune dysfunction, the virus can reactivate, which leads to lytic replication in a variety of...

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PMID: 33113934
DOI: 10.3390/pathogens9110869

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