Article

Alternative Promoters Drive Human Cytomegalovirus Reactivation from Latency

2018-12-01

Abstract excerpt

<h4>ABSTRACT</h4> Reactivation from latency requires reinitiation of viral gene expression and culminates in the production of infectious progeny. The major immediate early promoter (MIEP) of human cytomegalovirus (HCMV) drives the expression of crucial lytic cycle transactivators but is silenced during latency in hematopoietic progenitor cells (HPCs). Because the MIEP is poorly active in HPCs, it is unclear how...

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Literature Corpus work: b05b32a7-1af3-5ff5-9ba1-6a29296d6186
DOI: 10.1101/484436

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