Article

Host-encoded CTCF regulates human cytomegalovirus latency via chromatin looping

2023-09-18

Abstract excerpt

Human cytomegalovirus (HCMV) is a prevalent pathogen that establishes life-long latent infection in hematopoietic cells. While this infection is usually asymptomatic, immune dysregulation leads to viral reactivation, which can cause significant morbidity and mortality. However, the mechanisms underpinning reactivation remain incompletely understood. The HCMV major immediate early promoter (MIEP)/enhancer is a key...

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Literature Corpus work: fb9a9f82-c1c8-5fb5-9ad1-3c76a2e85fe6
DOI: 10.1101/2023.09.18.557586

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