Regulation of Human Cytomegalovirus Transcription in Latency: Beyond the Major Immediate-Early Promoter

Abstract excerpt

Lytic infection of differentiated cell types with human cytomegalovirus (HCMV) results in the temporal expression of between 170-200 open reading frames (ORFs). A number of studies have demonstrated the temporal regulation of these ORFs and that this is orchestrated by both viral and cellular mechanisms associated with the co-ordinated recruitment of transcription complexes and, more recently, higher order...

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