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Article

Epigenetic Control of Cytomegalovirus Latency and Reactivation

23 May 2013

Abstract excerpt

Cytomegalovirus (CMV) gene expression is repressed in latency due to heterochromatinization of viral genomes. In murine CMV (MCMV) latently infected mice, viral genomes are bound to histones with heterochromatic modifications, to enzymes that mediate these modifications, and to adaptor proteins that may recruit co-repressor complexes. Kinetic analyses of repressor binding show that these repressors are recruited...

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PMID: 23698401
DOI: 10.3390/v5051325

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