Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The interplay of mutations and electronic properties in disease-related genes.

Scientific reports - 1 Jan 2012

Shih Chi-Tin, Wells Stephen A, Hsu Ching-Ling, Cheng Yun-Yin, Römer Rudolf A

Abstract excerpt

Electronic properties of DNA are believed to play a crucial role in many phenomena in living organisms, for example the location of DNA lesions by base excision repair (BER) glycosylases and the regulation of tumor-suppressor genes such as p53 by detection of oxidative damage. However, the reproducible measurement and modelling of charge migration through DNA molecules at the nanometer scale remains a challenging...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Damage
Share to DNA Repair
Share to Electricity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Oxidative Stress

Share to Point Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 22355784
DOI: 10.1038/srep00272
PMCID: PMC3280594

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The interplay of mutations and electronic properties in disease-related genes.PMID 22355784Read ↗

Linking somatic mutations in cancer to the electronic properties of DNASemantic proximity Read ↗

Linking somatic mutations in cancer to the electronic properties of DNA.Semantic proximity Read ↗

DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification.Semantic proximity Read ↗

Human DNA Mutations and their Impact on Genetic Disorders.Semantic proximity Read ↗

Computational DNA hole spectroscopy: A new tool to predict mutation hotspots, critical base pairs, and disease 'driver' mutations.Semantic proximity Read ↗

More Insights into the Relation between DNA Ionization Potentials, Single Base Substitutions and Pathogenic MutationsSemantic proximity Read ↗

Computational and experimental approaches to reveal the effects of single nucleotide polymorphisms with respect to disease diagnostics.Semantic proximity Read ↗

Charge transport properties of ideal and natural DNA segments, as mutation detectors.Semantic proximity Read ↗

DNArCdb: A database of cancer biomarkers in DNA repair genes that includes variants related to multiple cancer phenotypes.Semantic proximity Read ↗

Local DNA dynamics shape mutational patterns of mononucleotide repeats in human genomes.Semantic proximity Read ↗

Protein molecular function influences mutation rates in human genetic diseases with allelic heterogeneity.Semantic proximity Read ↗

Single nucleotide polymorphisms in DNA glycosylases: From function to disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.