Article

Human Myelin Spheres for <i>In Vitro</i> Oligodendrocyte Maturation, Myelination and Neurological Disease Modeling

2025-05-28

Abstract excerpt

Demyelinating diseases, such as multiple sclerosis, damage the protective myelin sheaths of the central nervous system. The development of effective therapies has been hampered by the lack of models that accurately replicate human myelin biology. Here we present a novel method to generate human myelin spheres (MyS) by coculturing of hPSC-derived neuronal and oligodendrocyte precursor cells, to create myelinated ne...

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Literature Corpus work: 860c6c54-82a2-5bad-89c5-0c756d80e2e0
DOI: 10.1101/2025.05.28.656435

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