Article

White matter integrity requires continuous myelin synthesis at the inner tongue

2020-09-03

Abstract excerpt

<h4>Summary</h4> Myelin, the electrically insulating axonal sheath, is composed of lipids and proteins with exceptionally long lifetime. This raises the question how myelin function is affected by myelin turnover. We have studied the integrity of myelinated tracts after experimentally preventing the formation of new myelin in the CNS of adult mice, using an inducible Mbp null allele. Oligodendrocytes survived re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ea9e1c44-ec93-5977-a9e9-78f53e48f3bd
DOI: 10.1101/2020.09.02.279612

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

White matter integrity requires continuous myelin synthesis at the inner tongueDOI 10.1101/2020.09.02.279612Read

Oligodendrocytes form paranodal bridges that generate chains of myelin sheaths that are vulnerable to degeneration with ageSemantic proximity Read

Brain-wide mapping of oligodendrocyte organization and oligodendrogenesis across the murine lifespanSemantic proximity Read

Human Myelin Spheres for <i>In Vitro</i> Oligodendrocyte Maturation, Myelination and Neurological Disease ModelingSemantic proximity Read

Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and deathSemantic proximity Read

Genetically Labeled Premyelinating Oligodendrocytes: Bridging Oligodendrogenesis and Neuronal ActivitySemantic proximity Read

Development of a human pluripotent stem cell-derived in vitro model of myelinationSemantic proximity Read

Oligodendrocyte calcium signaling sculpts myelin sheath morphologySemantic proximity Read

Actin disassembly triggers CNS myelin compaction and wrappingSemantic proximity Read

Myelin lipids as nervous system energy reservesSemantic proximity Read

Remyelination reporter reveals prolonged refinement of spontaneously regenerated myelinSemantic proximity Read

New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelinationSemantic proximity Read

Mouse models of myelin diseases.Semantic proximity Read