Article

Impaired Myelination in Multiple Sclerosis Organoids: p21 Links Oligodendrocyte Dysfunction to Disease Subtype

2025-01-10

Abstract excerpt

<h4>ABSTRACT</h4> Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system. The cause of the disease is unknown but both genetic and environmental factors are strongly implicated in its pathogenesis. We derived cerebral and spinal cord organoids from induced pluripotent stem cells (iPSC) from healthy controls as well as from primary progressive MS (PPMS), secondary progressive M...

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Literature Corpus work: f68feb8a-8171-5838-9d49-01288f3e45f8
DOI: 10.1101/2025.01.08.631924

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