Article

Focal and subtle myelin damage in multiple sclerosis-derived post-mortem human brain slice cultures

2026-05-13

Abstract excerpt

The mechanisms that drive myelin damage as seen in demyelinating disorders such as multiple sclerosis remain incompletely understood. Much of our current knowledge is derived from animal models, but interspecies differences limit their relevance in the context of human pathology and could explain why various promising preclinical therapies failed during clinical translation. Human post-mortem organotypic brain sli...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6389d41d-13ca-59d8-b097-0a7e8be705cb
DOI: 10.64898/2026.05.09.723994

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Focal and subtle myelin damage in multiple sclerosis-derived post-mortem human brain slice culturesDOI 10.64898/2026.05.09.723994Read

Human Myelin Spheres for <i>In Vitro</i> Oligodendrocyte Maturation, Myelination and Neurological Disease ModelingSemantic proximity Read

Dynamic imaging of myelin pathology in physiologically preserved human brain tissue using third harmonic generation microscopySemantic proximity Read

An in vitro model for studying CNS white matter: functional properties and experimental approachesSemantic proximity Read

Development of a human pluripotent stem cell-derived in vitro model of myelinationSemantic proximity Read

In vitro myelination using explant culture of dorsal root ganglia: An efficient tool for analyzing peripheral nerve differentiation and disease modelingSemantic proximity Read

Development of passive CLARITY and immunofluorescent labelling of multiple proteins in human cerebellum: understanding mechanisms of neurodegeneration in mitochondrial disease.Semantic proximity Read

Myelination in cerebellar slice cultures: development of a system amenable to biochemical analysis.Semantic proximity Read

A rapid and versatile method for the isolation, purification and cryogenic storage of Schwann cells from adult rodent nerves.Semantic proximity Read

Disrupted myelin homeostasis in grey matter of Alzheimer’s diseaseSemantic proximity Read

A Nanoscale Model System for the Human Myelin SheathSemantic proximity Read

White matter integrity requires continuous myelin synthesis at the inner tongueSemantic proximity Read

Oligodendrocyte maturation alters the cell death mechanisms that cause demyelinationSemantic proximity Read