Article

Guidance receptor-mediated mechanocompliance of GBM cells facilitates immune-silent invasion

2025-12-06

Abstract excerpt

<h4>ABSTRACT</h4> The lethality of glioblastoma (GBM) stems from diffuse infiltration and immune evasion, two hallmarks traditionally studied separately. Here, we identify as unifying mechanism how GBM cells utilize guidance receptors Plexin-D1 and Plexin-B2 to gain mechanocompliance, i.e., the ability to deform and remodel membrane/cytoskeleton during confined migration without triggering immune activation. We s...

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Identifiers and source

Literature Corpus work: e4cf75ab-d661-5c9b-aa00-6912176f1f99
DOI: 10.64898/2025.12.03.692092

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