Back to search

Article

Bradykinesia and postural instability in a model of prodromal Synucleinopathy with α-Synuclein aggregation in the gigantocellular nuclei

2024-09-09

Abstract excerpt

<h4>ABSTRACT</h4> α-Synuclein (aSyn) accumulation within the extra-nigral neuronal populations in brainstem, including the gigantocellular nuclei (GRN/Gi) of reticular formation, is a recognized feature during the prodromal phase of Parkinson disease (PD). Accordingly, there is a burgeoning interest in animal model development for understanding the pathological significance of extra-nigral synucleinopathy, in rel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
85ff2c50-4bad-50f9-ab41-e02d68afab72
DOI
10.1101/2024.09.05.610956
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Bradykinesia and postural instability in a model of prodromal Synucleinopathy with α-Synuclein aggregation in the gigantocellular nucleiDOI 10.1101/2024.09.05.610956
A Summary of Phenotypes Observed in the In Vivo Rodent Alpha-Synuclein Preformed Fibril Model.Semantic proximity
A novel brainstem-targeted G51D α-synuclein fibril-injected mouse model exhibits sequential emergence of sleep and motor dysfunction.Semantic proximity
Molecular signatures of altered energy metabolism and circadian rhythm perturbations in a model of extra-nigral SynucleinopathySemantic proximity
Development and characterization of a non-human primate model of disseminated synucleinopathySemantic proximity
Circadian disruption coincides with morphological changes in the suprachiasmatic nucleus in a genetic α-synuclein rat model of early Parkinson's diseaseSemantic proximity
A novel mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein fibrils and recapitulates its pathological diversitySemantic proximity
Accelerated and Localized Synucleinopathy in a Hybrid Mouse Model: Implications for Positron Emission Tomography StudiesSemantic proximity
Striatal-Inoculation of α-Synuclein Preformed Fibrils Aggravated the Phenotypes of REM Sleep without Atonia in A53T BAC-SNCA Transgenic Mice.Semantic proximity
Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons.Semantic proximity
Modeling interregional propagation of α-synuclein in human striatal–midbrain assembloidsSemantic proximity
Long-term exposure to PFE-360 in the AAV-α-synuclein rat model: findings and implicationsSemantic proximity
Transgenic mice expressing human alpha-synuclein in noradrenergic neurons develop locus coeruleus pathology and non-motor features of Parkinson’s diseaseSemantic proximity
Select a neighboring publication to make it the new centre.